LSD

LSD (lysergic acid diethylamide) is a potent serotonergic psychedelic and probe of consciousness now emerging in geroscience. In C. elegans, LSD extended lifespan by ~25%, reduced age pigments, and mimicked caloric restriction via TOR modulation. Beyond the brain, it alters hormones, immune tone, and metabolism, with surveys linking psychedelic use to lower heart disease and diabetes. LSD may act as both a mind-expanding and lifespan-extending molecule.